CTO · MateBio
GraphRAG for a TechBio Startup
I led the transformation of raw biomedical knowledge graph data into a scalable, defensible, commercially viable platform. MateBio, a spin-off from the University of California, San Francisco, provided AI-powered tools that enabled wet lab researchers at biotech and pharma companies to explore complex biological relationships through natural language queries and interactive visualizations.
- Architected the core GraphRAG pipeline: a multi-tool LLM agent that turns natural-language biomedical questions into validated Cypher over a Neo4j knowledge graph spanning 80+ integrated data sources, with entity recognition, provenance tracking, and confidence scoring.
- Built a hybrid entity-resolution engine that maps imprecise researcher terms ("p53", "breast cancer") to exact graph identifiers, fusing heuristic biomedical NER, type-scoped full-text and vector search, and small-model disambiguation.
- Added a systems-biology analytics layer: Graph Data Science centrality (PageRank and personalized PageRank over pre-computed projections) plus a synthetic-EHR cohort service producing "signatures" that rank genes and pathways from clinical cohorts.
- Built multi-modal data ingestion so researchers could bring their own data alongside the graph: PDF and URL document RAG, plus CSV and omics analysis with auto-generated mermaid diagrams.
- Stood up the platform across two clouds (AWS and GCP, each running Neo4j and PostgreSQL) with Terraform-driven CI/CD, automated database migrations, and a tested cross-cloud migration path.
"Ezequiel has a commitment, responsibility, and adaptability that I have seen in very few professionals. His technical capabilities, learning ability, and personality make Ezequiel an excellent worker who can achieve any goal he sets before him."